Uromodulin as a potential candidate marker for predicting the course of chronic kidney disease

Uromodulin is a nephrospecific protein that most common in normal urine. And although it has been known for more than 70 years, the function of uromodulin remains unclear. involved regulating transport salts, protects against urinary tract infections, namely, mucous membrane bladder, and prevents formation kidney stones, as well plays role damage innate immunity. Serum urine, daily excretion per 1 milliliter creatinine clearance are actively studied. Complete genome studies association have established correlation between gene mutations autosomal dominant tubulointerstitial disease.